RosettaRemodel: a generalized framework for flexible backbone protein design.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21909381.
- Also identified by DOI 10.1371/journal.pone.0024109 and PMC identifier 3166072.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
We describe RosettaRemodel, a generalized framework for flexible protein design that provides a versatile and convenient interface to the Rosetta modeling suite. RosettaRemodel employs a unified interface, called a blueprint, which allows detailed control over many aspects of flexible backbone protein design calculations. RosettaRemodel allows the construction and elaboration of customized protocols for a wide range of design problems ranging from loop insertion and deletion, disulfide engineering, domain assembly, loop remodeling, motif grafting, symmetrical units, to de novo structure modeling.
Medical subject headings
- Computational Biology
- Models, Molecular
- Protein Conformation
- Proteins
- Software