Vaccine-induced cross-genotype reactive neutralizing antibodies against hepatitis C virus.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21917891.
- Also identified by DOI 10.1093/infdis/jir511 and PMC identifier 3203383.
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Abstract
We detected cross-reactive neutralizing antibodies (NtAb) against hepatitis C virus (HCV) in chimpanzees vaccinated with HCV-1 (genotype 1a) recombinant E1/E2 envelope glycoproteins. Five vaccinated chimpanzees, protected following HCV-1 challenge, were initially studied using the heterologous H77 (genotype 1a) HCVpp assay. All animals had developed NtAb after the second vaccination; 4 animals had reciprocal titers of ≥200 at the time of challenge. Using genotypes 1a-6a HCV pseudoparticles (HCVpp) and cell culture-derived HCV (HCVcc) assays, cross-reactive NtAb were detected against 1a, 4a, 5a, and 6a, with limited reactivity against 2a and 3a. Our study provides encouragement for the development of a recombinant envelope-based vaccine against hepatitis C.
Medical subject headings
- Antibodies, Neutralizing
- Hepacivirus
- Hepatitis C, Chronic
- Viral Envelope Proteins
- Viral Hepatitis Vaccines