The next level of complexity: post-transcriptional regulation by microRNAs.
Level V
Where this comes from
- Record sourced from PubMed, PMID 21918556.
- Also identified by DOI 10.1038/ki.2011.175.
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Abstract
MicroRNAs (miRNAs) are endogenous, small, noncoding RNAs that regulate expression of about half of human genes. Canonical miRNA biosynthesis involves two RNase III-type proteins, Drosha and Dicer. A podocyte-specific knockout of Dicer resulted in foot process effacement. In this issue, Zhdanova et al. report on targeting Drosha in a podocyte-specific fashion. Their study demonstrates an essential role of canonical miRNAs in maintaining the fully differentiated podocyte phenotype.
Medical subject headings
- Kidney Diseases
- MicroRNAs
- Podocytes
- Ribonuclease III