Transfer-printing of single DNA molecule arrays on graphene for high-resolution electron imaging and analysis.
basic_science · Level V
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- Record sourced from PubMed, PMID 21919532.
- Also identified by DOI 10.1021/nl202219w and PMC identifier 3205448.
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Abstract
Graphene represents the ultimate substrate for high-resolution transmission electron microscopy, but the deposition of biological samples on this highly hydrophobic material has until now been a challenge. We present a reliable method for depositing ordered arrays of individual elongated DNA molecules on single-layer graphene substrates for high-resolution electron beam imaging and electron energy loss spectroscopy analysis. This method is a necessary step toward the observation of single elongated DNA molecules with single base spatial resolution to directly read genetic and epigenetic information.