Cardiovascular pharmacogenomics.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 21921273.
- Also identified by DOI 10.1161/CIRCRESAHA.110.230995 and PMC identifier 3201825.
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Abstract
Patients vary in their responses to drug therapy, and some of that variability is genetically determined. This review outlines general approaches used to identify genetic variation that influences drug response. Examples from specific therapeutic areas are presented, such as cholesterol management, arrhythmias, heart failure, hypertension, warfarin anticoagulation, and antiplatelet agents. A brief view of potential pathways to implementation is presented.
Medical subject headings
- Cardiovascular Agents
- Cardiovascular Diseases
- Genetic Variation
- Pharmacogenetics