Tumor microvasculature targeting with dendrimer-entrapped gold nanoparticles.
basic_science · Level V
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- Record sourced from PubMed, PMID 21922025.
- Also identified by PMC identifier 3171797.
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Abstract
Monodisperse dendrimer-entrapped gold nanoparticles (diameter = 3.0 nm) were prepared using G5 poly(amidoamine) (PAMAM) dendrimer functionalized with fluorescein isothiocyanate (FI) and Arg-Gly-Asp (RGD) peptide as template; in vitro targeting efficacy to integrin receptor expressing cells was confirmed by flow cytometry, confocal microscopy, and ICP-MS.