SIP-ing the elixir of youth.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 21925309.
- Also identified by DOI 10.1016/j.cell.2011.08.026.
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Abstract
AMP-activated protein kinase (AMPK) is a conserved cellular fuel gauge previously implicated in aging. In this issue, Lu et al. (2011) describe how age-related deacetylation of Sip2, a subunit of the AMPK homolog in yeast, acts as a life span clock that can be wound backward or forward to modulate longevity.