A new shield for a cytokine storm.
editorial · Level V
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- Record sourced from PubMed, PMID 21925310.
- Also identified by DOI 10.1016/j.cell.2011.08.027 and PMC identifier 3645871.
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Abstract
Highly virulent influenza virus infection results in excessive cytokine production, recruitment of leukocytes, and immune-mediated pulmonary injury. Teijaro et al. (2011) now demonstrate that sphingosine-1-phosphate receptor 1 ligands suppress all features of flu-inflicted pathological inflammation and place the endothelium at the center of this regulatory network.