Synaptic plasticity of feeding circuits: hormones and hysteresis.
editorial · Level V
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- Record sourced from PubMed, PMID 21925311.
- Also identified by DOI 10.1016/j.cell.2011.08.031.
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Abstract
The drive to eat is controlled by neuronal circuits in the hypothalamus that respond to hormones signaling hunger or satiety. In this issue of Cell, Yang et al. (2011) reveal an AMPK-dependent synaptic pathway that sustains excitatory stimulation of the NPY/AgRP neurons that promote feeding behavior until satiety signals kick in.