Seroepidemiology of the newly found trichodysplasia spinulosa-associated polyomavirus.
cross_sectional · Level IV
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- Record sourced from PubMed, PMID 21926381.
- Also identified by DOI 10.1093/infdis/jir614.
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Abstract
Trichodysplasia spinulosa (TS)-associated polyomavirus (TSV) was recently (in 2010) discovered in TS lesions. To investigate the seroprevalence and primary exposure time of this virus, we set up a virus protein (VP1) viruslike particle (VLP)-based immunoglobulin G enzyme immunoassay. The seroprevalence of TSV was 5%, among children aged 1-4 years, rising to 48% at 6-10 years, and 70% among 149 adults. The TSV antibodies did not cross-react with corresponding Merkel cell polyomavirus VLPs, and their reactivity appeared conformational. TSV circulates widely in the human population and primary exposure is extensive in childhood, beginning at age 1-2 years.
Medical subject headings
- Antibodies, Viral
- Facial Dermatoses
- Immunoglobulin G
- Polyomavirus
- Polyomavirus Infections
- Tumor Virus Infections