Failure of topical antibiotics to prevent disseminated Borrelia burgdorferi infection following a tick bite in C3H/HeJ mice.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21930606.
- Also identified by DOI 10.1093/infdis/jir382 and PMC identifier 3415953.
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Abstract
A prior study in mice has shown that the timely application of topical antibiotics to the skin at the tick bite site could eradicate Borrelia burgdorferi infection. That study, however, did not evaluate antibiotic preparations that are considered suitable for use in humans. In this murine study, topical application of 2% erythromycin and 3% tetracycline preparations that are acceptable for use in humans was found to be ineffective in eliminating B. burgdorferi from the tick bite site or in preventing dissemination to other tissues. Reasons for the discrepant findings are discussed.
Medical subject headings
- Anti-Bacterial Agents
- Borrelia burgdorferi
- Erythromycin
- Lyme Disease
- Tetracycline