Atherosclerosis and dementia: a cross-sectional study with pathological analysis of the carotid arteries.
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 21940957.
- Also identified by DOI 10.1161/STROKEAHA.111.628156.
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Abstract
Previous ultrasound-based studies have shown an association between carotid artery atherosclerosis and dementia. Our aim was to investigate this association using postmortem examination. Postmortem morphometric measurements of carotid stenosis and intima-media thickness were performed in individuals with dementia (n=112) and control subjects (n=577). Multivariate logistic regression models were applied. High-grade left internal carotid stenosis (≥70%) was associated with increased odds for dementia (OR, 2.30; 95% CI, 1.14-4.74; P=0.02). Intima-media thickness was not associated with dementia. The likelihood of dementia is increased with high-grade left internal carotid artery atherosclerosis after adjusting for demographic and cardiovascular risk factors.
Medical subject headings
- Atherosclerosis
- Carotid Arteries
- Carotid Stenosis
- Dementia