Beyond VEGF: inhibition of the fibroblast growth factor pathway and antiangiogenesis.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 21953501.
- Also identified by DOI 10.1158/1078-0432.CCR-11-0659 and PMC identifier 5562355.
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Abstract
Fibroblast growth factor (FGF) signaling regulates cell proliferation, differentiation, survival, angiogenesis, and wound healing. Compelling evidence for deregulated FGF signaling in tumorigenesis continues to emerge, and a growing body of research suggests that FGF may also play an integral role in the resistance to anti-VEGF therapy. Although agents targeting FGF signaling are early in development, the potential to target both the VEGF and FGF pathways may translate into improvements in the clinical care of cancer patients.
Medical subject headings
- Fibroblast Growth Factors
- Neoplasms
- Vascular Endothelial Growth Factor A