DNA-coated microbubbles with biochemically tunable ultrasound contrast activity.

Nakatsuka, Matthew A; Hsu, Mark J; Esener, Sadik C; Cha, Jennifer N; Goodwin, Andrew P · Adv Mater · 2011

basic_science · Level V

Where this comes from

Abstract

Changing the mechanical properties of the microbubble shell in response to a biochemical stimulus leads to vast changes in both ultrasound-induced bubble dynamics and contrast-enhanced ultrasound imaging. Here, DNA-coated microbubbles are shown to be a simple and highly versatile platform that can silence and re-activate contrast activity in response to the introduction and removal of biochemical stimuli.

Medical subject headings