Suppression of cellular transformation by poly (A) binding protein interacting protein 2 (Paip2).
basic_science · Level V
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- Record sourced from PubMed, PMID 21957478.
- Also identified by DOI 10.1371/journal.pone.0025116 and PMC identifier PMC2275489.
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Abstract
Controlling translation is crucial for the homeostasis of a cell. Its deregulation can facilitate the development and progression of many diseases including cancer. Poly (A) binding protein interacting protein 2 (Paip2) inhibits efficient initiation of translation by impairing formation of the necessary closed loop of mRNA. The over production of Paip2 in the presence of a constitutively active form of hRas(V12) can reduce colony formation in a semi-solid matrix and focus formation on a cell monolayer. The ability of Paip2 to bind to Pabp is required to suppress the transformed phenotype mediated by hRas(V12). These observations indicate that Paip2 is able to function as a tumor suppressor.