Transplant glomerulopathy: it's not always about chronic rejection.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 21960169.
- Also identified by DOI 10.1038/ki.2011.192.
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Abstract
Transplant glomerulopathy (TG) is a morphologic lesion of renal allografts characterized by duplication of the glomerular basement membrane and is widely accepted as a manifestation of chronic antibody-mediated rejection (AMR). However, TG is not specific for chronic AMR, and this pattern of injury may result from a number of disease processes affecting the glomerular endothelium. Baid-Agrawal and co-workers consider three different, but not mutually exclusive, processes that can produce morphologic lesions of TG: chronic AMR, hepatitis C, and thrombotic microangiopathy.
Medical subject headings
- Graft Rejection
- Hepatitis C
- Kidney Diseases
- Kidney Glomerulus
- Kidney Transplantation
- Thrombotic Microangiopathies