Translocation mapping exposes the risky lifestyle of B cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21962501.
- Also identified by DOI 10.1016/j.cell.2011.09.005.
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Abstract
Recurrent chromosomal translocations can drive oncogenesis, but how they form has remained elusive. Now, Chiarle et al. (2011) and Klein et al. (2011) characterize the genome-wide spectrum of translocations that form from a single double-stranded break, revealing that specific loci have an intrinsic predisposition for frequent chromosomal rearrangements.