Leflunomide in dermatology.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 21962758.
- Also identified by DOI 10.1016/j.jaad.2011.08.025.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Leflunomide is an oral disease-modifying antirheumatic drug administered to patients with rheumatoid and psoriatic arthritis. This drug inhibits dihydroorotate dehydrogenase, an enzyme critical in the production of intracellular pyrimidines, and down-regulates tumor necrosis factor-alfa activity. Leflunomide has demonstrated usefulness in treating cutaneous psoriasis along with other dermatologic and rheumatologic conditions.
Medical subject headings
- Immunosuppressive Agents
- Isoxazoles
- Skin Diseases