Optimization of near-infrared fluorescent sentinel lymph node mapping for vulvar cancer.
prospective_cohort · Level II
Where this comes from
- Record sourced from PubMed, PMID 21963099.
- Also identified by DOI 10.1016/j.ajog.2011.07.039 and PMC identifier 3246078.
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Abstract
Near-infrared fluorescence imaging has the potential to improve sentinel lymph node mapping in vulvar cancer, which was assessed in the current study. Furthermore, dose optimization of indocyanine green adsorbed to human serum albumin was performed. Nine vulvar cancer patients underwent the standard sentinel lymph node procedure using (99m)technetium-nancolloid and patent blue. In addition, intraoperative imaging was performed after peritumoral injection of 1.6 mL of 500, 750, or 1000 μM of indocyanine green adsorbed to human serum albumin. Near-infrared fluorescence sentinel lymph node mapping was successful in all patients. A total of 14 sentinel lymph nodes (average, 1.6; range, 1-4) were detected: 14 radioactive (100%), 11 blue (79%), and 14 near-infrared fluorescent (100%). This study demonstrates feasibility and accuracy of sentinel lymph node mapping using indocyanine green adsorbed to human serum albumin. Considering safety, cost, and pharmacy preferences, an indocyanine green adsorbed to human serum albumin concentration of 500 μM appears optimal for sentinel lymph node mapping in vulvar cancer.
Medical subject headings
- Carcinoma
- Fluorescent Dyes
- Indocyanine Green
- Lymph Nodes
- Sentinel Lymph Node Biopsy
- Spectroscopy, Near-Infrared
- Vulvar Neoplasms