Breast cancer stem cells, cytokine networks, and the tumor microenvironment.
review · Level V
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- Record sourced from PubMed, PMID 21965337.
- Also identified by DOI 10.1172/JCI57099 and PMC identifier 3223613.
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Abstract
Many tumors, including breast cancer, are maintained by a subpopulation of cells that display stem cell properties, mediate metastasis, and contribute to treatment resistance. These cancer stem cells (CSCs) are regulated by complex interactions with the components of the tumor microenvironment - including mesenchymal stem cells, adipocytes, tumor associated fibroblasts, endothelial cells, and immune cells - through networks of cytokines and growth factors. Since these components have a direct influence on CSC properties, they represent attractive targets for therapeutic development.
Medical subject headings
- Breast Neoplasms
- Cytokines
- Neoplastic Stem Cells
- Tumor Microenvironment