eNERgizing pluripotent gene transcription.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21982224.
- Also identified by DOI 10.1016/j.stem.2011.09.004.
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Abstract
Nucleotide excision repair proteins are classically associated with DNA repair. However, a study by Fong et al. (2011) in the most recent issue of Cell demonstrates that the XPC/RAD23B/CETN2 nucleotide excision repair complex additionally functions as a transcriptional coactivator of Oct4/Sox2, critically regulating maintenance and reestablishment of stem cell pluripotency.