A panel of glycan cell surface markers define pluripotency state and promote safer cell-based therapies.
basic_science · Level V
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- Record sourced from PubMed, PMID 21982227.
- Also identified by DOI 10.1016/j.stem.2011.09.005.
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Abstract
In a recent study in Nature Biotechnology, Tang et al. (2011) describe a new marker of pluripotency, stage-specific embryonic antigen-5 (SSEA-5), and show that this oligosaccharide, together with two other surface antigens, can be used to remove all tumor-initiating cells from prospective cell transplants.