Estrogens and obesity: is it all in our heads?
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21982701.
- Also identified by DOI 10.1016/j.cmet.2011.09.003 and PMC identifier 4166555.
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Abstract
Estrogens have preventative effects on weight gain and associated comorbidities, but the tissue-specific targets remain unknown. Here, Xu et al. (2011) demonstrate that ablation of estrogen signaling in two populations of hypothalamic neurons leads to weight gain and subsequent metabolic dysregulation and could be important target sites of estrogen actions.