DisseCCTing phospholipid function in lipid droplet dynamics.
basic_science · Level V
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- Record sourced from PubMed, PMID 21982702.
- Also identified by DOI 10.1016/j.cmet.2011.09.002 and PMC identifier 3211137.
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Abstract
Phospholipids provide an amphipathic barrier between lipid droplets and the cytoplasm of cells. In this issue of Cell Metabolism, Krahmer and colleagues (2011) define a role for phosphatidylcholine in preventing lipid droplet coalescence and show that the rate-limiting enzyme in phosphatidylcholine synthesis is activated through binding to lipid droplets.