Assessment of rodents as animal models for Reston ebolavirus.
basic_science · Level V
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- Record sourced from PubMed, PMID 21987777.
- Also identified by DOI 10.1093/infdis/jir330 and PMC identifier 3189989.
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Abstract
The emergence of Reston ebolavirus (REBOV) in domestic swine in the Philippines has caused a renewed interest in REBOV pathogenicity. Here, the use of different rodent species as animal disease models for REBOV was investigated. BALB/c and STAT1(-)(/-) mice, Hartley guinea pigs, and Syrian hamsters were inoculated intraperitoneally with REBOV strain Pennsylvania or Reston08-A. Although virus replication occurred in guinea pigs, hamsters, and STAT1(-/-) mice, progression to disease was only observed in STAT1(-)(/-) mice. Moreover, REBOV Pennsylvania was more pathogenic than REBOV Reston08-A in this model. Thus, STAT1(-)(/-) mice may be used for research of REBOV pathogenicity and intervention strategies.
Medical subject headings
- Disease Models, Animal
- Ebolavirus
- Hemorrhagic Fever, Ebola