EGFR signaling in podocytes at the root of glomerular disease.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 21988993.
- Also identified by DOI 10.1038/nm.2455 and PMC identifier 4361890.
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Abstract
A study in a mouse model of immune-mediated glomerular disease and in people with rapidly progressive glomerulonephritis shows activation of epidermal growth factor receptor (EFGR) signaling in podocytes by a molecule expressed in the kidney (pages 1242–1250). Blocking this axis may open new doors to treat inflammatory kidney conditions.
Medical subject headings
- ErbB Receptors
- Glomerulonephritis
- Intercellular Signaling Peptides and Proteins
- Kidney Glomerulus
- Renal Insufficiency