Why don't CD8+ T cells reduce the lifespan of SIV-infected cells in vivo?
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21990968.
- Also identified by DOI 10.1371/journal.pcbi.1002200 and PMC identifier 3182865.
- Licence recorded as CC0.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
In January 2010 two groups independently published the observation that the depletion of CD8+ cells in SIV-infected macaques had no detectable impact on the lifespan of productively infected cells. This unexpected observation led the authors to suggest that CD8+ T cells control SIV viraemia via non-lytic mechanisms. However, a number of alternative plausible explanations, compatible with a lytic model of CD8+ T cell control, were proposed. This left the field with no consensus on how to interpret these experiments and no clear indication whether CD8+ T cells operated primarily via a lytic or a non-lytic mechanism. The aim of this work was to investigate why CD8+ T cells do not appear to reduce the lifespan of SIV-infected cells in vivo.
Medical subject headings
- CD8-Positive T-Lymphocytes
- Simian Acquired Immunodeficiency Syndrome
- Simian Immunodeficiency Virus