Automatic generation of protein structure cartoons with Pro-origami.

Stivala, Alex; Wybrow, Michael; Wirth, Anthony; Whisstock, James C; Stuckey, Peter J · Bioinformatics · 2011

basic_science · Level V

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Abstract

SUMMARY: Protein topology diagrams are 2D representations of protein structure that are particularly useful in understanding and analysing complex protein folds. Generating such diagrams presents a major problem in graph drawing, with automatic approaches often resulting in errors or uninterpretable results. Here we apply a breakthrough in diagram layout to protein topology cartoons, providing clear, accurate, interactive and editable diagrams, which are also an interface to a structural search method. AVAILABILITY: Pro-origami is available via a web server at http://munk.csse.unimelb.edu.au/pro-origami CONTACT: a.stivala@pgrad.unimelb.edu.au; pjs@csse.unimelb.edu.au.

Medical subject headings