Cyclooxygenase-2 in the kidney: good, BAD, or both?
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 21997504.
- Also identified by DOI 10.1038/ki.2011.263 and PMC identifier 3664549.
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Abstract
Hypertonic stress in the kidney inner medulla is common, yet inner medullary cells adapt to limit cell death. Küper et al. have identified a cell-survival response by which increased cyclooxygenase-2 (COX-2) stimulates a prostaglandin E(2) (PGE(2))/protein kinase A (PKA)-mediated inactivation of the pro-apoptotic protein BAD. However, the PGE(2)/PKA pathway is not the only means to inactivate BAD and limit cell death. This Commentary shows a broader picture of this pathway to examine the kidney's BAD options.
Medical subject headings
- Apoptosis
- Cyclooxygenase 2
- Epithelial Cells
- Kidney Medulla
- bcl-Associated Death Protein