A new regulator of the vacuolar H(+)-ATPase in the kidney.
Where this comes from
- Record sourced from PubMed, PMID 21997505.
- Also identified by DOI 10.1038/ki.2011.220.
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Abstract
Xu et al. identify Slc26a11, a novel member of the Slc26 anion exchanger family, as an electrogenic (Cl(-))(n)/HCO(3)(-) exchanger. Functional characterization of this transporter suggests that Slc26a11 mediates classical electroneutral Cl(-)/HCO(3)(-) exchange but also exhibits an electrogenic Cl(-) conductance. In the kidney, Slc26a11 colocalizes with the vacuolar H(+)-ATPase in intercalated cells, emphasizing the cooperation of the proton pump with chloride transporters.
Medical subject headings
- Anion Transport Proteins
- Chlorides
- Kidney Tubules, Collecting
- Vacuolar Proton-Translocating ATPases