Alignment of human vascular smooth muscle cells on parallel electrospun synthetic elastin fibers.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 21997972.
- Also identified by DOI 10.1002/jbm.a.33255.
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Abstract
We generated parallel elastic fibers from synthetic elastin (SE) as a model of the arterial media and assessed the alignment of smooth muscle cells (SMCs). SE utilized crosslinked electrospun human tropoelastin to form aligned fibers that mimicked the topography and elastin-rich content of the medial extracellular matrix. Bundled parallel fibers were anisotropically more elastic than randomly arranged scaffolds (111 ± 25 kPa vs. 265 ± 17 kPa) in the direction of the fibers. Aligned and random fiber scaffolds each supported SMC growth. Following attachment, SMCs proliferated longitudinally on the parallel fibers and expressed native α-smooth muscle actin.
Medical subject headings
- Elastin
- Muscle, Smooth, Vascular
- Myocytes, Smooth Muscle
- Tissue Engineering