The powerstroke and camshaft of the RIG-I antiviral RNA detection machine.
editorial · Level V
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- Record sourced from PubMed, PMID 22000004.
- Also identified by DOI 10.1016/j.cell.2011.09.027.
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Abstract
The innate immune sensor RIG-I responds to infection by binding to viral double-stranded RNA (dsRNA). In this issue of Cell, Kowalinski et al. (2011) and Luo et al. (2011) reveal the structure of RIG-I, and in combination with functional analyses, they show how RIG-I recognizes viral RNA to initiate signaling and a type I interferon response.