Genome-wide "re"-modeling of nucleosome positions.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22000006.
- Also identified by DOI 10.1016/j.cell.2011.09.042 and PMC identifier 3207319.
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Abstract
Two recent studies mapped nucleosomes across the yeast and human genomes, teasing apart the relative contributions of DNA sequence and chromatin remodelers to nucleosome organization. These data suggest two emerging models: chromatin remodelers position nucleosomes around transcriptional start sites in yeast, and a few "locked" nucleosomes may serve as barriers from which nucleosome arrays emanate in human genomes.
Medical subject headings
- Chromatin Assembly and Disassembly
- Genome, Fungal
- Genome, Human
- Nucleosomes