Hiding in plain sight: how HIV evades innate immune responses.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22000008.
- Also identified by DOI 10.1016/j.cell.2011.09.010 and PMC identifier 3624893.
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Abstract
Two groups have identified SAMHD1, a protein encoded by an Aicardi-Goutières Syndrome susceptibility gene, as the factor that restricts infection of macrophages and dendritic cells with HIV-1. Here we discuss implications of this discovery for induction of antiviral protective immunity.
Medical subject headings
- HIV Infections
- HIV-1
- Immune Evasion
- Immunity, Innate