Do MDL-1⁺ cells play a broad role in acute inflammation?
basic_science · Level V
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- Record sourced from PubMed, PMID 22005298.
- Also identified by DOI 10.1172/JCI60122 and PMC identifier 3204853.
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Abstract
Dengue virus (DV) reacts with myeloid DAP12-associating lectin-1 (MDL-1) on immature polymorphonuclear leukocytes. Interaction of DV with MDL-1+ cells triggers systemic inflammatory response syndrome (SIRS) and dengue shock syndrome (DSS), with subsequent multi-organ failure. In this issue of the JCI, Cheung et al. find that sterile acute liver injury in mice is associated with the accumulation of MDL-1+ cells and that triggering of these cells by DV or an MDL-1-specific agonist antibody leads to SIRS, shock, and death. These findings may have broad mechanistic and therapeutic implications for the development of SIRS, sepsis, and shock in humans exposed to a wide array of infectious and non-infectious conditions.
Medical subject headings
- Lectins, C-Type
- Myeloid Cells
- Receptors, Cell Surface
- Shock