PRINCIPLE: a tool for associating genes with diseases via network propagation.
Where this comes from
- Record sourced from PubMed, PMID 22016407.
- Also identified by DOI 10.1093/bioinformatics/btr584.
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Abstract
PRINCIPLE is a Java application implemented as a Cytoscape plug-in, based on a previously published algorithm, PRINCE. Given a query disease, it prioritizes disease-related genes based on their closeness in a protein-protein interaction network to genes causing phenotypically similar disorders to the query disease. Implemented in Java, PRINCIPLE runs over Cytoscape 2.7 or newer versions. Binaries, default input files and documentation are freely available at http://www.cs.tau.ac.il/~bnet/software/PrincePlugin/. roded@tau.ac.il; assafgot@tau.ac.il.
Medical subject headings
- Disease
- Software