Surfaces that sequester serum-borne heparin amplify growth factor activity.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22028244.
- Also identified by DOI 10.1002/adma.201103046 and PMC identifier 4410730.
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Abstract
Surfaces presenting a heparin-binding peptide can non-covalently sequester heparin from culture supplements, such as fetal bovine serum. In turn, sequestered, serum-borne heparin can non-covalently localize growth factors at the cell-material interface, resulting in amplified growth factor bioactivity.
Medical subject headings
- Fibroblast Growth Factor 2
- Heparin
- Peptide Fragments