Impact of inosine triphosphatase gene variants on the risk of anemia in HIV/hepatitis C virus-coinfected patients treated for chronic hepatitis C.
retrospective_cohort · Level III
Where this comes from
- Record sourced from PubMed, PMID 22028438.
- Also identified by DOI 10.1093/cid/cir665.
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Abstract
The role of rs1127354/rs7270101 alleles at the inosine triphosphatase (ITPA) gene on ribavirin-induced anemia was assessed in 74 patients with hepatitis C virus and human immunodeficiency virus coinfection. Anemia developed in 80% of patients with normal ITPA activity compared with 33% of those with reduced ITPA activity. In contrast, ITPA variants did not influence sustained virological response.
Medical subject headings
- Anemia
- Antiviral Agents
- HIV Infections
- Hepatitis C, Chronic
- Polymorphism, Genetic
- Pyrophosphatases
- Ribavirin