Prospective randomized evaluation of a collagen/thrombin and autologous platelet hemostatic agent during total knee arthroplasty.
rct · Level II
Where this comes from
- Record sourced from PubMed, PMID 22035976.
- Also identified by DOI 10.1016/j.arth.2011.09.014.
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Abstract
The purpose of this study was to evaluate the effectiveness of a collagen/thrombin and autologous platelet hemostatic agent in preventing blood loss during primary total knee arthroplasty. This prospective, double-blinded, randomized study was designed to enroll a total of 100 patients. Patients were randomized 1:1 to either the treatment arm (standard hemostasis plus study product) or the control arm (standard hemostasis alone). Transfusion requirements, as determined by a blinded investigator using standardized criteria, were significantly lower in the treatment group (no blood transfusions) compared with the control group (5 transfusions; P = .007). These data support the addition of the study product to prevent blood transfusions after primary total knee arthroplasty.
Medical subject headings
- Arthroplasty, Replacement, Knee
- Collagen
- Hemostasis, Surgical
- Postoperative Hemorrhage
- Thrombin
Anatomy
- knee