Dueling Ca2+ sensors in neurotransmitter release.
basic_science · Level V
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- Record sourced from PubMed, PMID 22036557.
- Also identified by DOI 10.1016/j.cell.2011.10.007 and PMC identifier 4061741.
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Abstract
Ca(2+)-triggered neurotransmitter release is characterized by two kinetically distinct components: a fast synchronous phase and a slow asynchronous phase. Yao et al. (2011) now report that double C2 domain (Doc2) proteins function as high-affinity Ca(2+) sensors to specifically regulate the asynchronous component of neurotransmitter release.