Molecular-genetic mapping of zebrafish mutants with variable phenotypic penetrance.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22039502.
- Also identified by DOI 10.1371/journal.pone.0026510 and PMC identifier PMC1207727.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Forward genetic screens in vertebrates are powerful tools to generate models relevant to human diseases, including neuropsychiatric disorders. Variability in phenotypic penetrance and expressivity is common in these disorders and behavioral mutant models, making their molecular-genetic mapping a formidable task. Using a 'phenotyping by segregation' strategy, we molecularly map the hypersensitive zebrafish houdini mutant despite its variable phenotypic penetrance, providing a generally applicable strategy to map zebrafish mutants with subtle phenotypes.