A PGC-1 tale: healthier intestinal stem cells, longer life.
basic_science · Level V
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- Record sourced from PubMed, PMID 22055499.
- Also identified by DOI 10.1016/j.cmet.2011.10.005.
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Abstract
PGC-1 regulates energy homeostasis and mitochondrial activity. In this issue, Rera et al. (2011) show that dPGC-1 overexpression in Drosophila intestinal stem cells and their immediate progeny extends organismal life span and protects against age-related loss of intestinal homeostasis and integrity, thereby establishing a link between mitochondria, tissue stem cells, and aging.