Nodal/Activin signaling: a novel target for pancreatic cancer stem cell therapy.
editorial · Level V
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- Record sourced from PubMed, PMID 22056131.
- Also identified by DOI 10.1016/j.stem.2011.10.006.
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Abstract
Targeting of cancer stem cells (CSCs) has the potential to address the recalcitrance of pancreatic cancer to chemotherapy. In this issue of Cell Stem Cell, Lonardo et al. (2011) demonstrate that Nodal/Activin signaling is crucial for the maintenance and tumor-initiating capacity of pancreatic CSCs.