Rewind to recover: dedifferentiation after cardiac injury.
editorial · Level V
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- Record sourced from PubMed, PMID 22056133.
- Also identified by DOI 10.1016/j.stem.2011.10.011 and PMC identifier 4212408.
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Abstract
In adult mammals, cardiomyocytes are known to reactivate an embryonic gene-expression program after injury. In this issue of Cell Stem Cell, Kubin et al. (2011) show that oncostatin M regulates this dedifferentiation which, while beneficial for recovery from acute injury, if persistent results in heart failure in both rodents and humans.