Guiding DNA methylation.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22056134.
- Also identified by DOI 10.1016/j.stem.2011.10.014.
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Abstract
How DNA methyltransferases, with their limited target specificity, establish cell-type-specific epigenetic patterns is poorly understood. Schübeler and colleagues (Lienert et al., 2011) now show that methylation-determining regions (MDRs) within promoter regions are sufficient to recapitulate endogenous patterns and dynamics of DNA methylation.