Age-specific prevalence of antibody to enterotoxigenic Escherichia coli in Ecuadorian and German children.
cross_sectional · Level IV
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Abstract
Serum samples from 1397 Ecuadorian children 0-5 years of age were tested by ELISA for antibodies to enterotoxigenic Escherichia coli (ETEC). A gradual prevalence and titer increase was seen for IgG antibodies to heat-labile enterotoxin in children 6-18 months old; 90% prevalences were reached in the second year of life. At this age less than 10% of West German children showed IgG antibodies to heat-labile enterotoxin. In Ecuador age-related ETEC-specific antibody titer increases correlated with age-related prevalence of diarrheal disease. On the other hand, pooled lipopolysaccharide from different ETEC-associated O serogroups could not be used as a seroepidemiologic marker of ETEC infections.
Medical subject headings
- Antibodies, Bacterial
- Diarrhea
- Diarrhea, Infantile
- Escherichia coli
- Escherichia coli Infections
- Escherichia coli Proteins