Isolation of prostate tumor initiating cells (TICs) through their dielectrophoretic signature.
basic_science · Level V
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- Record sourced from PubMed, PMID 22068834.
- Also identified by DOI 10.1039/c1lc20701f.
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Abstract
In this study, the dielectrophoretic response of prostate tumor initiating cells (TICs) was investigated in a microfluidic system utilizing contactless dielectrophoresis (cDEP). The dielectrophoretic response of prostate TICs was observed to be distinctively different than that for non-TICs, enabling them to be sorted using cDEP. Culturing the sorted TICs generated spheroids, indicating that they were indeed initiating cells. This study presents the first marker-free TIC separation from non-TICs utilizing their electrical fingerprints through dielectrophoresis.
Medical subject headings
- Cell Separation
- Electrophoresis
- Microfluidic Analytical Techniques
- Neoplastic Stem Cells
- Prostatic Neoplasms