Epstein-barr virus coinfection in cerebrospinal fluid is associated with increased mortality in Malawian adults with bacterial meningitis.
case_control · Level III
Where this comes from
- Record sourced from PubMed, PMID 22075766.
- Also identified by DOI 10.1093/infdis/jir707 and PMC identifier 3242746.
- Licence recorded as CC BY-NC.
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Abstract
Mortality from adult bacterial meningitis exceeds 50% in sub-Saharan Africa. We postulated that-particularly in individuals infected with human immunodeficiency virus (HIV)-herpes simplex virus, varicella zoster virus, Epstein-Barr virus (EBV), and cytomegalovirus (CMV) in the cerebrospinal fluid (CSF) contribute to poor outcome. CSF from 149 Malawian adults with bacterial meningitis and 39 controls were analyzed using polymerase chain reaction. EBV was detected in 79 of 149 bacterial meningitis patients. Mortality (54%) was associated with higher CSF EBV load when adjusted for HIV (P = .01). CMV was detected in 11 of 115 HIV-infected patients, 8 of whom died. The mechanisms by which EBV and CMV contribute to poor outcome require further investigation.
Medical subject headings
- Coinfection
- Cytomegalovirus
- Cytomegalovirus Infections
- Epstein-Barr Virus Infections
- Herpesvirus 4, Human
- Meningitis, Bacterial