Derepressing nuclear receptors for metabolic adaptation.
basic_science · Level V
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- Record sourced from PubMed, PMID 22078871.
- Also identified by DOI 10.1016/j.cell.2011.10.027.
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Abstract
NCoR is a corepressor of several transcription factors, including the PPAR family of nuclear receptors in fat and muscle. By specifically deleting NCoR in these tissues, Li et al. and Yamamoto et al. now uncover an important role for NCoR in regulating lipid homeostasis through the coordinated control of different nuclear receptors.