New driver for lipid synthesis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 22078872.
- Also identified by DOI 10.1016/j.cell.2011.10.019.
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Abstract
Cholesterol regulates activation of sterol regulatory element-binding protein (SREBP) through a classic feedback loop. Walker et al. (2011) extend the regulatory inputs governing SREBP activity to include an independent loop modulated by phosphatidylcholine (PC) and cellular methylation capacity. These findings suggest a link between lipid synthesis and cellular pathways involved in methylation.